A Drug Delivery System for Administration of Anti–TNF-a Antibody

نویسندگان

  • Marie-Claude Robert
  • Mathieu Frenette
  • Chengxin Zhou
  • Yueran Yan
  • James Chodosh
  • Frederick A. Jakobiec
  • Anna M. Stagner
  • Demetrios Vavvas
  • Claes H. Dohlman
  • Eleftherios I. Paschalis
چکیده

A Drug Delivery System for Administration of Anti–TNF-a Antibody Marie-Claude Robert, Mathieu Frenette, Chengxin Zhou, Yueran Yan, James Chodosh, Frederick A. Jakobiec, Anna M. Stagner, Demetrios Vavvas, Claes H. Dohlman, and Eleftherios I. Paschalis 1 Massachusetts Eye and Ear Infirmary, Department of Ophthalmology, Harvard Medical School, Boston, MA, USA 2 Massachusetts Eye and Ear Infirmary/Schepens Eye Research Institute, Boston Keratoprosthesis Laboratory, Harvard Medical School, Boston, MA, USA 3 Université du Québec à Montréal, Department of Chemistry, Montreal, QC, Canada 4 Massachusetts Eye and Ear Infirmary, Department of Ophthalmology, Angiogenesis Laboratory, Harvard Medical School, Boston, MA, USA 5 Massachusetts Eye and Ear Infirmary, David G. Cogan Laboratory of Ophthalmic Pathology, Harvard Medical School, Boston, MA, USA

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منابع مشابه

A Drug Delivery System for Administration of Anti-TNF-α Antibody.

PURPOSE To describe the fabrication, evaluation, and preliminary in vivo safety of a new drug delivery system (DDS) for topical anti-TNF-α antibody administration. METHODS A DDS was fabricated using inverse template fabrication of a hydrophobic three-dimensional porous scaffold (100-300 μm in diameter porosity) loaded with 10% polyvinyl alcohol hydrogel carrying 5 mg/ml (weight/volume) of ant...

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تاریخ انتشار 2016